A Review on Structural Insights into NLRP3 and NEK7: Domain Architecture, Subcellular Localization, and Their Interaction in Inflammasome Assembly and Signaling
Jan 2026· Molecular Neurobiology· Vol 63· 0 citations· 117 references
Medicine
TL;DR
The structural domains and subcellular localizations of NLRP3 and NEK7 are examined, and how their interaction promotes inflammasome assembly is highlighted, to address key unanswered questions that may guide future research into therapeutic modulation of these essential protein–protein interactions.
Inflammasomes ignite innate immune defense in response to infectious pathogens and noninfectious dangers, primarily through sensors composed of nucleotide-binding domain (NBD), leucine-rich repeat (LRR)-containing (NLR) family proteins. NLRP6 is an inflammasome sensor that plays critical roles in regulating intestinal...
Zhen Cui, Qi Sheng, Minsoo Son et al.· Nature Structural & Molecula...· 0 citations
Inflammasomes are multiprotein complexes that orchestrate immune responses to pathogenic and sterile insults by regulating the maturation of inflammatory cytokines and pyroptotic cell death. While inflammasome activation is well-characterized at the biochemical level, the mechanisms governing the spatial and temporal a...
Teresa Nava-Ramírez, C. Cuevas-Velazquez, Alejandra A. Covarrubias et al.· Frontiers in Immunology· 0 citations
The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome plays a crucial role in host defense; however, its aberrant activation leads to excessive release of pro-inflammatory cytokines, triggering inflammatory responses and tissue damage in human diseases. In this study, the inhibitory effect...
Bin Jia, Abuduwaili Zulalai, Huai-Ping Tang et al.· European Journal of Pharmaco...· 0 citations
Deletion of MEX3B inhibited caspase-4 and gasdermin D activation, pyroptosis, and secretion of inflammasome-dependent inflammatory cytokines in human cell lines and murine primary macrophages and suggested that MEX3B is a pan-inflammasome regulator targeting inflammatory caspases.
Peng-Hua Wang, Jason G. Cahoon, Duo-Meng Yang et al.· Journal of Immunology· 0 citations
ABSTRACT The NLRP3 inflammasome is a multi‐protein complex that plays a crucial role in inflammatory processes mediated by the innate immune system. Dysregulated NLRP3 activation has been implicated in age‐related inflammatory diseases, making it a promising therapeutic target. Here, we report that the synthetic membra...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin et al.· Advancement of science· 0 citations
Obesity has become a significant public health issue in both industrialized and developing nations, growing substantially over recent decades. Emerging evidence supports a central role for the purinergic P2X7 receptor along with the NLRP3 inflammasome as intermediary mediators linking metabolic stress and inflammatory...
