A Review on Structural Insights into NLRP3 and NEK7: Domain Architecture, Subcellular Localization, and Their Interaction in Inflammasome Assembly and Signaling
The structural domains and subcellular localizations of NLRP3 and NEK7 are examined, and how their interaction promotes inflammasome assembly is highlighted, to address key unanswered questions that may guide future research into therapeutic modulation of these essential protein–protein interactions.