TL;DR
It is hypothesize that slide helix position in the membrane might possibly act as a "conformational switch" in regulating the KirBac1.1 function, and results involving dynamic lipid-protein interactions in lipid-dependent gating might be relevant for other Kir channels.
This work identified the key molecular determinant in the hHv1 channel that mediates cholesterol inhibition and also provided a mechanism linking the conversion between demosterol and cholesterol by DHCR24 to pH homeostasis in many cells, such as phagocytes, cardiomyocytes, neurons and microglial cells.
This paper reports on a plausible mechanism of modulation by anionic phospholipids of KcsA, a model prokaryotic potassium channel. A first conclusion is that the association of anionic phospholipids with KcsA occurs at discrete regions located near both the extracellular and intracellular channel gates. This same behav...
The binding sites of the channel for various ligands/modulators are highlighted, and an emerging model focusing on the structural rearrangements associated with the transition of the channel from the closed/deactivated to open/activated conformation during lipid-dependent gating is provided which should be broadly appl...
Mechanosensitive channels of large conductance (MscL) protect bacteria from hypo-osmotic stress by opening a large pore in response to membrane tension. The transmembrane TM1 and TM2 helices together with the N-terminal amphipathic helix function as the primary force-sensing structural domains, whereas the role of the...
Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is permeable to Ca2+ when activated b...
Helix 8 in G protein-coupled receptors (GPCRs) has recently been linked to receptor internalization (Schmidt et al.,2025, Sci. Adv. 11, eadv1499), but the molecular basis of this relationship remains unclear. Here, we examined a proposed mechanism in which helix 8 functions as a surface-active amphipathic element that...
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