Zeylenone-mediated inhibition of TIMP-1-induced Bax/Bcl-2/Cle-caspase-3 expression and apoptosis via FAK-PI3K/AKT pathway regulation in thyroid cancer cells: in vitro and in silico study

Robinin modulates TIMP-1/FAK/PI3K/Akt/mTOR-related signaling and induces oxidative stress-associated apoptotic responses in KB cells: in vitro and in silico evidence

ROS-Activated SHP-1 Signaling Underlies Artesunate-Mediated Inhibition of EMT and STAT3-Driven Prostate Cancer Progression.

Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is a hallmark of prostate cancer (PC) progression. Here, we investigated the anticancer effects of artesunate (ART) and its underlying mechanisms in PC. ART selectively reduced the viability of PC cells with minimal toxicity toward no...

Sophocarpine Inhibits Proliferation and Triggers Apoptosis in Breast Cancer Cells by Modulating the miR-21/PTEN/AKT and ERK1/2 Signaling Networks

Background: Sophocarpine (SC), a tetracyclic quinolizidine alkaloid, has shown antitumor potential, yet its activity and underlying mechanisms in breast cancer remain unexplored. This study aimed to investigate the anticancer effects of SC and the molecular mechanism, focusing on the involvement of microRNA-21 (miR-21)...

Bullatine A Attenuates Proliferation in Breast Cancer Cells by Apoptosis via PI3K/AKT/mTOR Signaling Pathway in Vitro and in Silico Analysis and Pharmacological Analysis

Allicin activates ER stress-induced IRE1α-JNK pathway and apoptosis via caspase-3/9 in BT-549 cell line

Breast cancer continues to represent a major contributor to cancer-related mortality, creating a severe public health burden worldwide. Adjuvant therapy is essential for nearly fifty percent of breast cancer patients following surgery to mitigate recurrence. Consequently, the use of effective chemotherapeutic agents to...

PD16, a steroidal saponin, induces apoptosis in colorectal cancer via inhibiting the AKT/GSK3β signaling pathway.

Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality globally. PD16, a novel steroidal saponin from Paris delavayi Franchet, shows cytotoxicity against HepG2 and U87MG cells, but its anti-CRC effects and related molecular mechanisms remain unknown. Our study revealed that PD16 significantly...