Open access
Jul 2026
Zeylenone-mediated inhibition of TIMP-1-induced Bax/Bcl-2/Cle-caspase-3 expression and apoptosis via FAK-PI3K/AKT pathway regulation in thyroid cancer cells: in vitro and in silico study
It is demonstrated that zeylenone suppresses proliferation and promotes apoptosis in TPC-1 cells primarily through suppression of the TIMP-1-mediated FAK/PI3K/AKT signaling pathway, highlighting its potential as a therapeutic candidate for thyroid carcinoma.
Shi-Chen Qin, Jie Zhou, Xuemei Wu et al.
· 3 Biotech · 0 citations