Aug 2026· Endocrine pathology· Vol 37· 0 citations· 176 references
Medicine
TL;DR
A refined, bladder-specific framework that incorporates proliferative indices, molecular alterations, and recognition of mixed neuroendocrine–non-neuroendocrine neoplasms is proposed, with the goal of improving diagnostic reproducibility and informing future biomarker-driven therapeutic strategies.
Low membranous Nectin-4 expression and preferential DLL3 and SLFN11 expression in High-NE tumours support further investigation of alternative therapeutic strategies, and SmCCB may be stratified into two IHC-defined phenotypic groups with distinctive neuroendocrine differentiation and therapeutic biomarker profiles.
N. Tenace, M. Colecchia, A. Hartmann et al.· Histopathology· 0 citations
Background. Breast neuroendocrine neoplasms (BNETs) represent a rare and heterogeneous subgroup of breast cancers, comprising 2-5% of all breast carcinomas. Their classification has undergone significant changes following the WHO 2019 and 2022 revisions, which redefined diagnostic criteria and introduced new subtypes....
Jonasz Żuk, K. Bukała, Szymon Klimaszewski et al.· International Journal of Inn...· 0 citations
The immunological features of representative neuroendocrine and adrenal tumors (neuroendocrine tumor, neuroendocrine carcinoma, adrenocortical carcinoma, and pheochromocytoma/paraganglioma) are examined, suggesting a potential benefit observed in selected subgroups.
A. Ohmoto, Shunji Takahashi, Shigehisa Kitano· Cancer Medicine· 0 citations
Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis, divides lung NETs into grade-1 typical, and grade-...
A. Sexton-Oates, É. Mathian, N. Candeli et al.· Molecular Cancer· 1 citation
Neuroendocrine neoplasms (NENs) are a biologically heterogeneous group of epithelial malignancies arising from neuroendocrine cells across multiple organs. Although considered rare in comparison to other solid tumors, their incidence has increased more than six-fold in recent decades. A major clinical challenge is the...
Timothy Khumpan, Kasonde Chewe, Namrata Vijayvergia et al.· Human Genomics· 0 citations
This is a narrative review that describes the evolution of terminology and classification schemes of neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), mixed neuroendocrine–non-neuroendocrine neoplasms (MiNENs), and paragangliomas of the larynx, with the contribution of immunohistochemistry and treatment o...
Martina Bradová, Abbas Agaimy, A. Ferlito· Diagnostics· 0 citations
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