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Neuroendocrine Neoplasms of the Urinary Bladder: Integrating Molecular Advances into a Refined Classification System
A refined, bladder-specific framework that incorporates proliferative indices, molecular alterations, and recognition of mixed neuroendocrine–non-neuroendocrine neoplasms is proposed, with the goal of improving diagnostic reproducibility and informing future biomarker-driven therapeutic strategies.
PYGO2 Ablation Promotes Lymphoid Organization and STING-Dependent Antitumor Immunity in Prostate Cancer.
Prostate cancer is an immunologically cold tumor with a limited response to immune checkpoint blockade. Although tertiary lymphoid structures (TLSs) are associated with favorable immunotherapeutic outcomes in various malignancies, the tumor-intrinsic mechanisms governing their formation in prostate cancer remain poorly...