Aug 2026· Macromolecules· 0 citations· 56 references
Abstract
The multiscale architecture of alginate–gelatin–hyaluronic acid (AGH) hydrogels was elucidated using a synergistic approach of swelling tests, mechanical characteristics, TEM, and SAXS; it was demonstrated that, in AGH, a crosslinked alginate network coexists with non-interconnected cavities composed of uncrosslinked polymer strands. While swelling analysis yields a mesh size of ξS = (12 ± 3) nm corresponding to the alginate network, mechanical measurements reveal an effective mesh size ξM–eff = (44 ± 2) nm, reflecting the combination of the viscoelastic network and cavity contributions. SAXS identifies two rod-like crosslink-site populations (∼1 and ∼4 nm); the latter was directly validated by TEM, and these populations were found in the swollen and dried states to be independent of alginate content. These findings establish the porosity of the cavities, ϕ, as the key structural parameter to predict AGH mechanical properties from those of pure alginate, providing a framework for designing complex bio-based composites.
This study focuses on the synthesis of a bio‐based, viscoelastic hydrogel derived from sodium alginate with enhanced adhesive properties suitable for diverse applications. The hydrogel network was formed through free radical polymerization, employing N, N′‐methylene bisacrylamide (MBA) as a crosslinking agent to es...
Muhammad Tahir Khan, Arooba Shehzad, Nadia Naeem et al.· Journal of Applied Polymer S...· 0 citations
Hydrogels have garnered significant interest as soft materials due to their flexibility, high water content, and biocompatibility. Alginate/polyacrylamide (Alg/PAAm) double-network (DN) hydrogels are particularly promising for wearable electronics, strain sensors, and soft electrolytes owing to their toughness and stru...
Taeuk Eom, Hyunseung Kim, Ji-Hun Choi et al.· Chemistry· 0 citations
The introduction of reversible physical cross-linking constitutes a viable strategy for fabricating hydrogels with excellent mechanical properties, efficient self-recovery, and shape-memory capability. In this study, tannic acid-functionalized cellulose nanofibrils (TA@CNF) served as the core functional filler and we...
Three-dimensional, interconnected hydrogel networks are central to tissue engineering and disease modeling, where tailored pore architecture and mechanical robustness are essential for supporting cellular functions. However, the limited ability to engineer microstructural features in vat polymerization 3D-printed natur...
Liwei Liu, Liwen Zhang, Xumin Huang et al.· Small Methods· 0 citations
In this study, novel 3D bioprinted composite scaffolds were developed using Polyvinyl alcohol (PVA), chitosan (CS), sodium alginate (Alg), and turmeric (Tur) to investigate their potential as advanced bioactive platforms for wound healing and drug delivery. The scaffolds were fabricated via extrusion-based bioprinting,...
Alp Erdogan Oztürk, Fatih Ciftci, A. C. Calikoglu Koyuncu et al.· Journal of The Mechanical Be...· 0 citations
