Skip to content

Exploring Parental Factors in Autism Spectrum Disorder Risk: A Case-Control Study

Aug 2026 · Maternal and Child Health Journal · Vol 30, pp. 1161 - 1166 · 0 citations · 19 references
Medicine

TL;DR

A familial background of autism, male gender, premature birth, and admission to a neonatal intensive care unit were notably more prevalent in children with autism, underscoring populations who may require enhanced developmental monitoring.

View source

Similar papers

Aug 2026

Gender-Based Differences in Autism Spectrum Disorder: Evidence From an Indian Clinical Cohort.

Although the observed 4:1 ratio aligns with global trends, the findings suggest under-identification of females, and gender-sensitive diagnostic tools are needed to improve detection and understanding of ASD in females.

Nishant Prabhakaran, S. Kaku, Ann Maria Moncy et al. · 0 citations
Open access 2026

Parental Knowledge of Autism Spectrum Disorder in Parents of Children Aged 18–36 Months: A Cross-Sectional Study

Objectives: This study aims to explore the level of knowledge about autism spectrum disorder (ASD) in parents aged 18–36 months. Methods: This cross-sectional descriptive study was performed in 354 parents with 18–36-month-old children between August 01, 2022, and January 31, 2023, in family health care centers. Participants were evaluated face-to-face with sociodemographic data and the modified early childhood screening (modified checklist for autism in toddlers [M-CHAT]) Scale. It is the assessment of ASD and a 23-question scale. Results: Of the study, 65.3% participants were female, and the mean age of parents was 34.9±5.7 years. Almost all parents reported to having heard of a disease called autism. 68.9% stated that the diagnosis should be performed by an experienced physician through clinical examination and observation, whereas 81.6% reported that they would consult a clinician immediately if their child’s speech was delayed. Another striking result emerging from our analyses was that, although the participants had heard of ASD before, the most authoritative source of information was social media. The question with the highest number of correct answers was asked whether your child should look at you when calling their name. The question with the lowest number of correct answers was that your child does not play imaginary games. Additionally as the parents' educational level of increased M-CHAT scores, of children being identified as high risk for ASD, based on significantly decreased. Conclusion: This study showed that parents had limited knowledge of autism. Educational status and having children were found to be associated with autism awareness. If the parents recognize the symptoms of autism in their child, they can seek medical help.

Tuğba Babacan Gadiş, Mahcube Çubukçu · 0 citations
Open access Aug 2026

Parental broader autism phenotype and its association with adolescent social anxiety

Objective: Social anxiety disorder (SAD) and autism spectrum disorder (ASD) share overlapping social-cognitive features. The broader autism phenotype (BAP), reflecting subclinical autistic traits in parents, may be relevant in understanding adolescent social anxiety within a family context. This study aimed to examine the association between parental BAP traits and social anxiety severity in adolescents. Materials and Methods: In this study, 109 adolescents with SAD (aged 11–17 years, 79.8% female) and their parents (109 mothers and 109 fathers) were included. Adolescents completed the Social Anxiety Disorder Severity Scale–Child Version, while parents completed the Autism Spectrum Quotient (AQ) and the Social Responsiveness Scale (SRS), used as a secondary exploratory measure of social functioning. Non-parametric analyses and binary logistic regression were performed. Results: Greater SAD severity was associated with lower paternal AQ scores (ρ=–0.29, p=0.002). In addition, adolescents in the higher-severity SAD group had significantly higher SRS scores compared to those in the lower-severity group (p=0.003). Conclusion: Parental BAP traits, particularly paternal autistic traits, may be associated with social anxiety severity in adolescents. However, due to the cross-sectional design, reliance on questionnaire-based measures, and potential shared-informant bias, these findings should be interpreted cautiously and considered hypothesis-generating rather than confirmatory.

Şermin Bilgen Ulgar, Mehtap Eroğlu, Neşe Yakşi et al. · 0 citations
Open access 2026

Burden on the caregivers of children and adolescents with autism spectrum disorder: which variables are related?

ABSTRACT Purpose To evaluate the factors associated with the burden of caregivers of children and adolescents with autism spectrum disorder (ASD), identifying which variables have the greatest impact on their daily lives. Methods The study evaluated 19 caregivers of children with ASD, aged 2 to 12 years; 18 were boys (94.7%). The diagnosis was made by a multidisciplinary team, and the participants were under the care of a pediatric neurologist. The variables collected included the child's age and sex, comorbidities (intellectual disability, attention-deficit/hyperactivity disorder, and so forth), current complaints, type of ongoing intervention, score on the Childhood Autism Rating Scale (CARS), caregiver age, number of children, and family income. Caregiver burden was assessed using the Zarit Burden Interview. Statistical analysis used linear regression with a stepwise selection method to identify the factors significantly associated with burden. Results only the CARS score was significantly associated with caregiver burden (p = 0.0077), indicating that higher levels of impairment in ASD are related to greater burden. The patients’ age and sex, comorbidities, current complaints, intervention at the time of assessment, and socioeconomic level were not significant. Conclusion The severity of ASD symptoms, reflected by the CARS score, was the main factor associated with caregiver burden. Other aspects, such as age, comorbidities, and socioeconomic level, may also exert influence, as described in the literature, but were not statistically significantly associated in this study.

Laraflay Viana dos Santos, P. Zuanetti, Larissa Maria de Vito Pimenta et al. · 0 citations
Open access Aug 2026

Sibling influence on childhood neurodevelopmental disorders: A cohort study in Taiwan.

OBJECTIVE Autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), cerebral palsy (CP), and developmental delay are major childhood neurodevelopmental disorders. Sibling status and birth order may influence neurodevelopmental outcomes, yet population-based evidence remains limited. This study examined their associations with childhood neurodevelopmental disorder risks in a nationwide birth cohort. METHODS We analyzed 2,045,178 live births from Taiwan's Birth Registration Database (2004-2014), linked to National Health Insurance and Death Registry records through 2020. CP, developmental delay, ASD, and ADHD were identified using ICD codes. Children were classified by sibling status and birth order using maternal identifiers. Kaplan-Meier and Cox models estimated adjusted hazard ratios (aHRs), controlling for maternal age, birth period, perinatal factors, socioeconomic status, and urbanization. RESULTS Compared with single children, those with siblings generally showed lower risks of CP and ASD, whereas associations with ADHD and developmental delay varied according to birth order. Later birth order was associated with lower recorded risks of ASD and ADHD. Similar patterns were observed after excluding multiple births and in analyses restricted to diagnoses before 6 years of age. CONCLUSIONS Family structure, including single-child status and birth order, was associated with childhood neurodevelopmental disorder risks. Compared with children who had siblings, single children generally had higher risks across multiple neurodevelopmental outcomes. These findings suggest that family structure may represent an important early-life context for neurodevelopment and may help inform developmental surveillance in societies experiencing declining fertility rates and delayed childbearing.

Yi-Yu Su, Chi-Jen Chen, Mei-Huei Chen et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.