Comprehensive Profiling of ac4C RNA Modification Identifies CERCAM in Cancer‐Associated Fibroblasts as a Key Prognostic and Microenvironmental Regulator in Colorectal Cancer

Abstract

N4‐acetylcytidine (ac4C) RNA modification has emerged as a critical epigenetic regulator in tumorigenesis and progression. However, the comprehensive landscape of ac4C modification in colorectal cancer (CRC), particularly its orchestration of the tumor microenvironment (TME) and stromal crosstalk, remains largely unexplored.