Open access
Chronic Inhalation of Sulphureous Water Mitigates Early Amyloid Pathology and Associated Microglial Changes in 5XFAD Mice
Martina Bodria
Eleonora Daini
Stefano Pioli
M. Piemontese
E. Vandini
A. Ottani
Michele Zoli
Daniela Giuliani
A. Vilella
Abstract
Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive decline and behavioral impairments. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that exerts pleiotropic neuromodulatory, anti-inflammatory, cytoprotective, and trophic effects within the central nervous system.