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EZH2 expression in diffuse large B-cell lymphoma: clinicopathological associations and relationship with survival
Mehmet Mutlu Kıdı
Mehmet Turker
Sedat Biter
M. Ergin
T. Toyran
T. Köşeci
Hatice Asoğlu
Yasemin Aydınalp Camadan
I. Kara
Berksoy Şahin
E. Bayram
Abstract
Purpose: Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator implicated in the pathogenesis of diffuse large B-cell lymphoma, but the prognostic value of its protein expression is uncertain. We evaluated EZH2 expression and its associations with clinicopathological features and survival.Materials and Methods: We retrospectively studied 50 patients with diffuse large B-cell lymphoma treated with rituximab-based immunochemotherapy. EZH2 expression was assessed by immunohistochemistry using an H-score and classified as high (≥150) or low (