It is found that microbiota promote host early-life fitness, at the cost of amplifying metabolic stress and inflammation later in life, and postulate that microbiota promote host early-life fitness, at the cost of amplifying metabolic stress and inflammation later in life.
Current evidence represents the microbiota–mitochondria axis as a one of the promising mechanistic and therapeutic targets for neurodegenerative and ocular diseases, however, most therapeutic evidence discussed in this review is derived from preclinical studies, with relatively limited clinical validation.
Puneet K. Samaiya, Akshat Agrawal, Shrija Kesharwani et al.· Frontiers in Pharmacology· 0 citations
The crosstalk between the gut microbiota and the host redox system is essential for maintaining intestinal homeostasis and systemic health. Disruption of this bidirectional interaction impairs redox balance, promotes oxidative stress, and contributes to the initiation and progression of a wide range of diseases, includ...
Shuai-Hu Chen, Yu-Long Yin, Jie Yin et al.· Antioxidants· 0 citations
Examination of evidence surrounding mitochondrial dysfunction, oxidative stress, and gut microbiome dysbiosis across humans, mice, and fruit flies under spaceflight and corresponding terrestrial control conditions finds that biomarker genes most associated with mutation accumulation and antagonistic pleiotropy appear t...
C. Naney, J. Graves, Scott H. Harrison· International Journal of Mol...· 0 citations
Abstract Sepsis is a life-threatening disorder caused by dysregulated host responses to infection, characterized by immune dysfunction, metabolic reprogramming, and multi-organ injury. Mitochondria, beyond their role in energy metabolism, act as central signaling hubs that integrate cellular metabolism, innate immunity...
Jia-Qi Li, Yu-Ting Sun, Mei-Lin He et al.· Journal of Inflammation Rese...· 0 citations
The gut microbiome is viewed as a dynamic and potentially modifiable component of immune aging rather than an autonomous driver of immunosenescence, and this perspective shifts the translational focus from restoring a youthful microbiome toward targeting microbiome-associated functions and host-response pathways linked...
Bo-Wen Jiang, Tian-Hao Liu, Wen-Hui Duan et al.· Ageing Research Reviews· 0 citations
The gut microbiota is linked to age-dependent immune remodeling in the brain and imply that altered microbial communities could influence pro-inflammatory T-cell responses, thereby contributing to accelerated brain aging.
Laura Peschke, Tinh Thi Nguyen, J. Leite et al.· Gut microbes· 0 citations
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