Lack of tau expression modifies epileptogenesis associated neuroplasticity in the ventral dentate gyrus in a mouse model of temporal lobe epilepsy

Parvalbumin interneurons and dentate gyrus homeostatic dysregulation shape epileptogenesis in Angelman syndrome model mice

Enhanced HCN-Dependent Regulation of Temporoammonic Integration and Entorhinal–Hippocampal Epileptiform Coupling Following Febrile Seizures

Local targeted suppression of neocortical spreading depolarization amplitude by viral expression of KCa3.1 channels.

Forniceal deep brain stimulation improves memory in Rett syndrome mice by promoting the maturation of newborn hippocampal neurons.

Deep brain stimulation (DBS) is associated with an increase in hippocampal neurogenesis and memory benefits, but the causal mechanism is unclear. Here, we use a mouse model of Rett syndrome, a severe learning disability syndrome caused by MECP2 loss of function, to find that DBS promotes the maturation and integration...

Antithetical roles of tau in hippocampal long-term synaptic depression in rats versus mice

Synaptic dysfunction is a primary feature of tauopathies, a group of major neurodegenerative diseases that includes Alzheimer’s disease. However, the normal synaptic functions of tau are poorly understood. Since rats provide advantages over mice for understanding human tau, such as expressing six tau isoforms and showi...

The postsynaptic scaffold protein ABLIM1 regulates seizure susceptibility by maintaining GluA2 membrane localization in chronic epilepsy.

Temporal lobe epilepsy (TLE), the most common form of drug-resistant epilepsy (DRE) in adults, is a frequent chronic neurological disorder. Nevertheless, the precise pathophysiological mechanisms underlying TLE remain largely undefined. Our findings demonstrate that Actin-binding LIM protein 1 (ABLIM1) is broadly expre...