Synthesis and Evaluation of Anti-Influenza Activity of Amide Derivatives of 3-Spiro-1,2,4-trioxolanolithocholic Acid

Synthesis and antiproliferative evaluation of thiophene-coupled azetidin-3-ylamino quinoline-3-carbonitrile derivatives

A novel series of (substituted)-1-methyl-2-oxo-4-(1-(thiophene-2-carbonyl)azetidin-3-ylamino)-1,2-dihydroquinoline-3-carbonitrile derivatives (5a–5m) was synthesized from substituted 2-aminobenzoic acids (1a–1g) via 1H-benzo[d][1,3]oxazine-2,4-diones (2a–2g). A straightforward route was established for the synthesis of...

Design and synthesis of novel 4-substituted 1,4-dihydropyridine (DHP) derivatives, molecular docking and anti-oxidant activity

Abstract A new series of 1,4-dihydropyridine derivatives bearing a benzoic acid at the N-position were prepared by Hantzsch syntheses with piperidine as the catalyst, enamine of dimedone and 2-benzylidenemalononitrile as starting materials. Various substituted substrates were successfully used, affording the N-substitu...

Synthesis and Biological Activities of New 3-Amino Derivatives of Methyl 2-oxo-1-(2,2,2-trifluoroethyl)-1,2-dihydroquinoxaline-6-carboxylate

3-Amino derivatives of methyl 2-oxo-1-(2,2,2-trifluoroethyl)-1,2-dihydroquinoxaline-6-carboxylate (7a-l) were prepared using methyl 4-chloro-3-nitrobenzoate (1) as the starting material. The synthesized derivatives were characterized by 1H NMR, mass and IR spectroscopy. The derivatives were tested for their antibacteri...

Synthesis, characterization and molecular docking studies of novel 6-Imino-2-Methyl-4-substituted- 6H -1,3-Thiazine-5-Carbonitrile derivatives as potential antibacterial agents

Favourable binding energies and significant intermolecular interactions highlight these thiazine derivatives as promising leads for further antibacterial development.

SYNTHESIS AND SOME BIOLOGICAL PROPERTIES OF DERIVATIVES OF 2,3-DISUBSTITUTED 5,5-DIMETHYL-BENZO[H]QUINAZOLIN-4(1H)-ONES.

Design, synthesis, and cytotoxic activity evaluation of 1,2,4-Triazole-based Ethanone and Ferrocenylchalcone derivatives: A comparative study.

The TA derivatives demonstrated a more favorable balance between antiproliferative potency, tumor selectivity, and effects on wound-closure than the corresponding TAFe complexes, although selected TAFe derivatives exhibited cell line-dependent selectivity.