Metastatic immune microenvironment remodeling by malignant epithelial cells drives colorectal cancer hepatic metastasis: Multi-omics insights

Abstract

Highlights • First identified Scissor⁺ malignant cells driving CRC HM.• Constructed a Scissor-related prognostic signature for CRC patients with HM.• Elucidated mechanisms of Scissor⁺ malignant cells worsen the microenvironment of HM.• Firet confirmed Scissor⁺ malignant cells polarize macrophages into SELENOP⁺ TAMs.