Lymphatic networks enable diversification of B cell responses to vaccines

Lymphatic constraint of germinal centers optimizes protective antibody responses

Summary Immunization strategies are central to pathogen control, where efficacy relies on antigen distribution and inflammatory context. Lymphatic vessels are necessary conduits for antigen transport that actively remodel in peripheral tissues and draining lymph nodes (LN) in response to their inflammatory context. In...

Tumor-infiltrating B cells in cancer immunity: heterogeneity, spatial organization, and context-dependent function.

Tumor-infiltrating B cells are emerging as critical regulators of cancer immunity. Recent single-cell and spatial studies have shown that their functions extend beyond antibody production to include antigen presentation, tertiary lymphoid structure (TLS) organization, T cell modulation, cytokine-mediated regulation, an...

Immunoregulatory artificial lymph nodes restore antigen-specific tolerance in advanced multiple sclerosis.

Tolerogenic dendritic cell (tolDC) vaccines are a promising antigen-specific therapy for multiple sclerosis (MS), yet their efficacy is limited by poor homing to secondary lymphoid organs and rapid loss of the tolerogenic phenotype in native inflamed lymph nodes. Here, we developed a 3D-printed tolerogenic artificial l...

Temporal and transcriptional programming of effector memory B cells shapes vaccine platform-dependent humoral immunity

Findings show that influenza vaccination drives platform-dependent diversification of HA-specific B cell states, highlighting the need for vaccine-platform-specific correlates of immune protection.

Distributed apoptotic checkpoints in B cell selection, tolerance, and autoimmunity

Generating a diverse B cell repertoire is essential for protective immunity, yet the required genetic alterations inevitably produce self-reactive, damaged, and non-competitive cells. To maintain immune homeostasis and ensure effective humoral immune responses, recent evidence supports the concept that a distributed ne...

The spatial architecture of tumor immunity: Emerging predictive biomarkers across cancer