N-linked glycans are ubiquitous post-translational modifications that mediate diverse biological processes, including cell signaling and adhesion, molecular recognition, and host-pathogen interactions. Despite their importance, N-linked glycans have largely remained beyond the reach of biomolecular design due to a lack...
Margaret C. Lunn-Halbert, J. D. Allen, Rohith Krishna et al.· bioRxiv· 0 citations
L lymphatic networks diversify B cell fate, repertoire and affinity selection, and antibody isotype, revealing a programmable axis for tuning humoral immunity through vaccine design.
Jaime L. Chao, C. Thouvenel, Courtney E. McDougal et al.· bioRxiv· 0 citations
Pneumoviruses cause seasonal outbreaks leading to hospitalizations of vulnerable populations such as infants and the elderly. Cross-neutralizing antibodies targeting viral fusion have been isolated from infected individuals, but their elicitation and mechanisms of action remain understudied. Here, we describe two vacci...
S. Ols, Rodrigo Arcoverde Cerveira, A. J. Borst et al.· bioRxiv· 0 citations
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