TL;DR
Sulforaphane dose-dependently improved renal function, histopathological alterations, behavioral performance, and brain antioxidant and anti-inflammatory status and may be associated with modulation of the Nrf2/NLRP3 signaling pathway.
ZIN protects against D-galactose-induced cognitive and motor deficits by enhancing antioxidant and anti-inflammatory activity in the hippocampus and attenuate histopathological changes in the cortex and hippocampal areas of D-gal-induced brain aging rats.
Alzheimer's disease (AD) is a neurodegenerative ailment characterized by neuronal and cognitive dysfunctions. Notably, cysteinyl leukotriene receptor 1 (CysLT1R) overexpression was detected in various AD models. It was closely associated with other hallmarks of AD, including increased oxidative stress, neuroinflammatio...
Preclinical evidence is provided that metformin can attenuate behavioral alterations associated with prenatal VPA exposure and modulate oxidative stress‐related markers, with patterns varying across sexes and brain regions.
AIM Ketamine (KTM) is widely used in clinical settings for its anesthetic, analgesic, and antidepressant properties. However, prolonged or repeated KTM exposure can induce neurotoxicity through oxidative stress, neuroinflammation, and apoptotic mechanisms. This study investigated the neuroprotective effects of Chrysin...
Background/Introduction: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss, oxidative stress and mitochondrial dysfunction. Current therapies mainly provide symptomatic relief without preventing disease progression. Carnosic acid (CA), a natural phenolic di...
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