Author

Doaa A. Ghareeb

2 papers indexed here

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Aug 2026

Sulforaphane mitigates behavioral deficits in experimental chronic kidney disease through regulation of Nrf2/NLRP3 inflammasome.

Sulforaphane dose-dependently improved renal function, histopathological alterations, behavioral performance, and brain antioxidant and anti-inflammatory status and may be associated with modulation of the Nrf2/NLRP3 signaling pathway.

Hend S Zakaria, M. T. Ghoneim, Doaa A. Ghareeb et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations

Open access Sep 2026

Novel pyrimidine-based N-Acylhydrazones as dual AChE inhibitors and antioxidants targeting Alzheimer's disease.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by cholinergic dysfunction and oxidative stress, making the development of multi-target-directed ligands (MTDLs) an attractive therapeutic strategy. Herein, we designed and synthesized a novel series of pyrimidinone-based acyl hydrazo...

M. N. Abd Al Moaty, A. Moustafa, Alaa S. Hegazy et al. · Bioorganic chemistry (Print) · 0 citations