Magnolol confers neurotrophic effects against MPTP/p-induced Parkinson’s disease in mice via anti-inflammatory, anti-apoptotic mechanisms and PI3K/AKT/GSK3β/MAPK/mTOR signalling regulation

Norepinephrine modulates the microglial response and protects against MPTP-induced Parkinson's disease pathology through regulation of the PI3K/AKT/mTOR pathway.

AIMS Norepinephrine (NE) deficiency is an early and prominent feature of Parkinson's disease (PD), but its specific contributions to pathogenesis have not been fully elucidated. This study aims to determine whether NE exerts neuroprotective effects in PD models through the modulation of autophagy and microglial activat...

Neuroprotective Mechanisms of Paeoniflorin in Parkinson’s Models: Involvement of BDNF-Dependent PI3K/Akt and ERK/CREB Pathways

Paeoniflorin, a bioactive monoterpene glycoside derived from Paeonia lactiflora, has shown neuroprotective effects primarily associated with the promotion of brain-derived neurotrophic factor secretion. This study aims to elucidate the therapeutic potential of paeoniflorin in models of Parkinson’s disease and to invest...

Combined rituximab and magnesium acetyl taurate therapy attenuates neurodegeneration via ERK/c-JNK/P38MAPK signaling modulation in methylmercury-induced amyotrophic lateral sclerosis-like neurotoxicity.

It is suggested that RTXMB, particularly in combination with MACT600, exerts potent neuroprotective effects against ALS-like pathology via modulation of MAPK signaling pathways and may represent a promising therapeutic strategy for ALS management.

Targeting the AMPK/SIRT1-NLRP3 Inflammasome Axis: Simvastatin, Ezetimibe, and Their Combination Attenuate 3-Nitropropionic Acid-Induced Striatal Neurodegeneration in Rats.

Collectively, Simvastatin and Ezetimibe attenuate 3-NP-induced striatal neurodegeneration, possibly through modulation of AMPK/SIRT1-associated neuroinflammatory and glial signaling pathways, warranting further evaluation in additional experimental models.

Dose-dependent effects of fingolimod on behavioral, molecular, and Stereological outcomes in a rat model of intracerebroventricular streptozotocin-induced Alzheimer’s disease-like cognitive dysfunction

Fingolimod exerted dose-dependent, domain-specific effects, with lower doses improving functional outcomes and the intermediate dose providing greater preservation of hippocampal structure, suggesting beneficial effects within the doses examined.

Neuroprotective effects of dapansutrile in rotenone-induced parkinsonism: targeting NLRP3/caspase-1, NF-κB, Nrf2/HO-1, and PINK1/Parkin pathways.