Oct 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 133 references
Medicine
TL;DR
It is suggested that RTXMB, particularly in combination with MACT600, exerts potent neuroprotective effects against ALS-like pathology via modulation of MAPK signaling pathways and may represent a promising therapeutic strategy for ALS management.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, characterized by the deposition of amyloid-β plaques in the hippocampus, leading to cognitive and behavioral impairments. This study investigated the neuroprotective outcome of Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor primarily...
Lovekesh Singh, G. Das Gupta, Shamsher Singh· Assay and drug development t...· 0 citations
The results indicate the cognitive improvement and neuroprotective effects of DMF in Aβ1-42 CE model by modulating the necroptosis signalling and suggest that the selective targeting of necroptosis process may open new treatment avenues for AD.
Sandeep Guin, Aditi Jangli, Manoj P. Dandekar· International Immunopharmaco...· 0 citations
It is suggested that FMNT attenuates PTZ-kindling-associated seizure severity and cognitive deficits, potentially through antioxidant effects and suppression of P2 X 7/IL-1β/glutamate-associated inflammatory signalling.
Harsh Yadav, B. Thawkar, Nisarg S. Sawant· Neurochemical Research· 0 citations
AIMS
Norepinephrine (NE) deficiency is an early and prominent feature of Parkinson's disease (PD), but its specific contributions to pathogenesis have not been fully elucidated. This study aims to determine whether NE exerts neuroprotective effects in PD models through the modulation of autophagy and microglial activat...
Huan Yin, Dan Zhao, Yun-Fu Wang· Experimental Neurology· 0 citations
Collectively, Simvastatin and Ezetimibe attenuate 3-NP-induced striatal neurodegeneration, possibly through modulation of AMPK/SIRT1-associated neuroinflammatory and glial signaling pathways, warranting further evaluation in additional experimental models.
A. Rezqallah, Eman M. Raafat, Shahira Nofal· Neuropharmacology· 0 citations
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