[Hepatocellular carcinoma-derived lactate-mediated histone H3K18 lactylation modifies S100A2 transcription to promote proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells].

[MIS18BP1 regulates epithelial-mesenchymal transition, proliferation, and migration of renal cancer cells via the PI3K/AKT pathway].

METTL3-mediated m6A modification of PARP2 accelerates hepatocellular carcinoma progression.

Results showed that PARP2 was highly expressed in hepatocellular carcinoma and related to its poor prognosis, and METTL3-mediated PARP2 m6A modification plays a vital tumor-promoter role in hepatocellular carcinoma progression.

P4HA3 promotes gastric cancer cell proliferation and invasion via the PI3K/AKT/mTOR signaling pathway and regulates glycolytic metabolic reprogramming

Experimental data indicated that P4HA3 facilitated GC cell proliferation, migration and invasion, and enhanced glycolytic activity and increased the expression of key glycolysis-related proteins, suggesting that P4HA3 may induce a broader metabolic activation rather than an exclusively glycolytic shift.

E3 Ubiquitin Ligase MDM2 Contributes to Proliferation, Migration/Invasion, Epithelial-Mesenchymal Transition, and Glycolytic Reprogramming in Lung Cancer via Ubiquitinating and Degrading MYH11 Protein.

Lung cancer remains the leading cause of cancer-associated death, and aerobic glycolysis is a key hallmark of cancer. Ubiquitination is a post-translational modification involved in the regulation of lung cancer progression. The aim of this study was to investigate E3 ubiquitin ligase mouse double minute 2 (MDM2) and i...

FOXP1 transcriptionally activates NUSAP1 to induce M2 polarization of tumor-associated macrophages via glycolysis in hepatocellular carcinoma

A novel mechanism by which FOXP1 transcriptionally upregulates NUSAP1 expression results in glycolytic metabolic reprogramming that induces TAM M2 polarization and promotes HCC progression, identifying a potential therapeutic avenue for reversing the immunosuppressive microenvironment in HCC.

Lactate-Induced H3K18 Lactylation Attenuates T-Cell Activation and Upregulates PD-L1 in Esophageal Squamous Cell Carcinoma

Background: Immune checkpoint blockade targeting the Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) axis has demonstrated clinical activity in esophageal squamous cell carcinoma (ESCC). However, therapeutic responses remain limited in a substantial proportion of patients. Metabolic reprogramming and lactat...