TL;DR
Findings highlight the toxicological relevance of metal mixtures in cardiovascular disease and underscore the need for mechanistic studies to establish causality.
Exposure to metal mixtures is significantly associated with obesity in U.S. children, with manganese showing the strongest association and Cd, Pb, and Co showing the strongest negative associations.
The findings suggest an association between urinary multi-metal mixtures and adult asthma but do not establish causality and suggest potential nonlinear and pairwise patterns involving multiple metals, particularly U, Ti and vanadium (V), but these findings were exploratory and do not establish synergistic toxicity.
Insulin resistance might be a crucial mediated pathway between Se and outcomes and three multi-pollutant models revealed positive associations between metal mixtures and SUA as well as HUA, with Se being the primary contributor.
BACKGROUND Accumulation of metals in the human body results from the interplay between environmental exposure-primarily through diet-and genetic susceptibility. Genome-wide association studies (GWAS) enable hypothesis-free identification of single-nucleotide polymorphisms (SNPs) associated with metal levels, but eviden...
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