TL;DR
Exposure to metal mixtures is significantly associated with obesity in U.S. children, with manganese showing the strongest association and Cd, Pb, and Co showing the strongest negative associations.
Findings highlight the toxicological relevance of metal mixtures in cardiovascular disease and underscore the need for mechanistic studies to establish causality.
Introduction: Hypertension is a major public health challenge worldwide. In low- and middle-income countries, hypertension is rapidly increasing and contributes substantially to premature mortality. It is commonly associated with overweight and obesity. Growing evidence also indicates that environmental pollutants, par...
The findings suggest an association between urinary multi-metal mixtures and adult asthma but do not establish causality and suggest potential nonlinear and pairwise patterns involving multiple metals, particularly U, Ti and vanadium (V), but these findings were exploratory and do not establish synergistic toxicity.
Regulating key PM2.5 chemical constituents is a vital public health strategy to mitigate the adverse effects of prenatal air pollution on children's metabolic health, and these findings underscore that regulating key PM2.5 chemical constituents is a vital public health strategy.
Insulin resistance might be a crucial mediated pathway between Se and outcomes and three multi-pollutant models revealed positive associations between metal mixtures and SUA as well as HUA, with Se being the primary contributor.
Integrative epidemiological, mechanistic, and experimental evidence implicates Cd-induced oxidative stress, inflammation, and tissue remodeling as key pathogenic processes in chronic obstructive pulmonary disease.
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