This pilot study provides some of the first estimates of PFAS exposure among prostate cancer patients in serum and tap water, showing moderate correlations between tap water and serum concentrations of specific PFAS analytes.
It is suggested that higher plasma PFAS concentrations, particularly HFPO-DA, may be associated with more advanced TNM stage in colorectal cancer and warrant confirmation in larger prospective studies.
Ning Kang, Yang Zhao, Zhi Huang et al.· Frontiers in Toxicology· 1 citation
Mixture exposure showed a significant positive association with chronic obstructive pulmonary disease risk, and these substances disrupt pulmonary homeostasis through concurrent molecular activation and lipid-metabolic disturbance, evidenced by triglyceride-glucose index mediation.
Yansong Hu, Huanyu Cui, Yakun Wang et al.· BMC Pulmonary Medicine· 0 citations
The findings suggest that exposure to low levels of some alternative and precursor PFAS may be widespread in Canada and reinforce the role of pregnancy and breastfeeding as excretion pathways for legacy PFAS and support previous investigations demonstrating that exposure to some PFAS may be lower amongst financially disadvantaged populations.
M. Borghese, Rebecca Lelievre, Sara Packull-McCormick et al.· Environmental Health· 0 citations
Exposure to per- and polyfluoroalkyl substances (PFASs) has been associated with hypertension in some populations, but the associations among young men and underlying mechanisms remain unclear. We measured 16 plasma PFAS and assessed obesity and hypertension (blood pressure ≥130/80 mmHg) among 1283 Chinese young men. In total, 449 (35.0%) men had hypertension. Plasma 6:2 fluorotelomer phosphate diester (6:2 diPAP) concentrations were positively associated with hypertension in a linear dose–response manner (OR = 1.09, 95% CI: 1.01–1.16 per 2.7-fold increase), with an OR of 1.43 (1.07–1.90) for the highest versus lowest exposure tertile. Individual obesity indicators (body mass index [BMI], waist circumference, and waist-to-height ratio [WHtR]) explained 8.6%–19.2% of the association between 6:2 diPAP and hypertension. A machine learning-derived three-level obesity severity spectrum integrating WHtR and BMI (normal, elevated central adiposity alone, and elevated central adiposity with overweight) explained 36.9% of the association. In summary, exposure to 6:2 diPAP was associated with higher odds of hypertension among young men, partly mediated by obesity, with an integrated body shape pattern combining central and general adiposity showing the largest mediating effect.
Li-Li Huang, Na Ji, Huiling Shao et al.· Environment & Health· 0 citations
This protocol explores applying the target trial emulation framework to improve causal inference in environmental epidemiology by emulating a target trial of a hypothetical PFAS-reduction intervention using observational data from the Copenhagen City Heart Study.
Georges Khoury, L. Deen, Lars Christian Lund et al.· Toxics· 0 citations
The need to reassess the biosafety of novel PFAS alternatives is underscores the need to reassess the biosafety of novel PFAS alternatives and provides new insights into the environmental etiology of breast cancer.
Bei Sun, Zhanhua Gao, Xi-Yue Liu et al.· Frontiers in Public Health· 0 citations
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