Associations between legacy and emerging per and polyfluoroalkyl substances (PFAS) bioaccumulation and clinicopathological characteristics in breast cancer

Serum concentrations of legacy, alternative, and precursor per- and polyfluoroalkyl substances: a descriptive analysis of premenopausal participants in the Canadian CARTaGENE cohort

The findings suggest that exposure to low levels of some alternative and precursor PFAS may be widespread in Canada and reinforce the role of pregnancy and breastfeeding as excretion pathways for legacy PFAS and support previous investigations demonstrating that exposure to some PFAS may be lower amongst financially disadvantaged populations.

Per- and Polyfluoroalkyl Substances (PFAS) in Terrestrial Mammals from a Typical Chinese Agricultural Region: Non-Target Screening, Biomagnification, and Risk Assessment

With perfluoroalkyl and polyfluoroalkyl substances (PFAS) widely distributed across environmental media and prone to bioaccumulation, terrestrial mammals face ecological health risks, yet related research remains limited. This study addresses the gap by investigating the occurrence and biomagnification of PFAS in terrestrial mammals in a typical agricultural region in China. Using non-target analysis, fifteen PFAS from twelve classes were identified with confidence level 2. Total PFAS concentrations ranged from 0.121 to 0.386 ng/g wet weight (ww) in hares, 0.086 to 0.434 ng/g ww in hedgehogs, and 0.306 to 0.973 ng/g ww in weasels. For 15 PFAS examined except PFHxDA and PFODA, biomagnification factors were found to be greater than 1 in both the hare-weasel and hedgehog-weasel food chains, indicating significant biomagnification of PFAS in hare-weasel and hedgehog-weasel food chains. A risk-based prioritization approach was developed to rank the identified PFAS, flagging four as high priority (risk index > 0.1). These findings enhance understanding of PFAS behavior in terrestrial ecosystems and provide valuable insights to mitigate their environmental and ecological impacts.

Per- and polyfluoroalkyl substances mixture exposure is associated with colorectal cancer TNM stage

It is suggested that higher plasma PFAS concentrations, particularly HFPO-DA, may be associated with more advanced TNM stage in colorectal cancer and warrant confirmation in larger prospective studies.

Revealing the Link Between Exposure to Per- and Polyfluoroalkyl Substances (PFAS) and Stroke: A Comprehensive Epidemiological and Network Toxicology Perspective

Occurrence, biomagnification, and health risk assessment of per- and polyfluoroalkyl substances (PFASs) in marine organisms from western coast of the Yellow Sea.

Per- and polyfluoroalkyl substances (PFASs) received widespread concern due to their persistent, bioaccumulative potential and health impacts. In the present study, 33 legacy and emerging PFASs were analyzed in nine marine species from western coast of the Yellow Sea. The concentrations of PFASs ranged from 109.14 to 483.13 ng/g dry weight (dw), and 29.24 to 101.71 ng/g wet weight (ww). Perfluorooctanoic acid (PFOA) was the predominant congener, accounting for 24.7-61.1% of total PFASs. Positive correlation was observed between field-calculated log BAFs and model prediction values. Based on stable isotope analysis (δ13C and δ15N), a marine food web was constructed to evaluate trophic transfer. Trophic magnification factor (TMF) of total PFASs was 2.25, confirming the biomagnification ability of PFASs. Perfluorononanoic acid (PFNA, TMF = 4.72) and N-ethyl perfluorooctane sulfonamidoacetic acid (N-EtFOSAA, TMF = 6.64) exhibited the highest amplification, whereas short-chain PFASs and 8:2 chlorinated polyfluoroether sulfonate displayed trophic dilution. The estimated daily intakes (EDI) of four priority PFASs (22.2 ng/kg bw/day) exceeded the EFSA tolerable weekly intake of 0.63 ng/kg bw/week, indicating potential health concerns associated with local seafood consumption. These findings reveal pervasive contamination in marine organisms from western coast of the Yellow Sea.

The Occurrence of Emerging Per- and Polyfluoroalkyl substances (PFAS) in Indoor Dust from Different Microenvironments in South China.

Despite extensive research on the environmental contamination of per- and polyfluoroalkyl substances (PFAS), their occurrence across diverse indoor microenvironments remains insufficiently characterized. In this study, we analyzed a broad spectrum of PFAS in dust samples collected from residential settings (n = 14) and six types of public environments in South China between July and September 2022, using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry (UPLC-MS/MS). Of the 35 target compounds, 19 PFAS were detected with detection frequencies exceeding 50%. Ultrashort-chain perfluoroalkyl acids (PFAAs) and their precursors emerged as the dominant species, with concentrations substantially higher than those of legacy compounds such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). PFAS concentrations varied by microenvironment, with offices exhibiting the highest levels (median 516 ng/g), likely attributable to the widespread use of PFAS-containing materials and confined space. Estimated exposure via dust ingestion revealed that toddlers experienced the highest intake (0.692 ng/kg/day) among all age groups in household environments, due to greater dust ingestion rates. Our study highlights the widespread occurrence of emerging PFAS, including ultrashort- and short-chain PFAAs and PFAA precursors, in indoor environments in South China and emphasizes the importance of ongoing surveillance and regulatory measures for these substances.