Aug 2026· Translational Oncology· Vol 72, pp. 102936· 0 citations· 78 references
Medicine
TL;DR
Silencing SLC2A3 reduces the malignant phenotypes of irradiated NPC cells and enhances NPC cell radiosensitivity, partly in association with reduced MAPK pathway activation.
Abstract
Highlights • Silencing SLC2A3 reduces the malignant phenotypes of irradiated NPC cells.• SLC2A3 knockdown decreases tumorigenicity in irradiated NPC xenograft-bearing mice.• SLC2A3 knockdown enhances NPC cell radiosensitivity, partly in association with reduced MAPK pathway activation.
Simple Summary Osteosarcoma survival drops to ~20% after lung metastasis, highlighting the need for new therapies. This study shows that matrine, a natural compound from Sophora flavescens, suppresses osteosarcoma growth and lung metastasis in vitro and in vivo by directly inhibiting PI3K/AKT signaling, thereby inducin...
Highlights • MATR3 is significantly upregulated in colorectal cancer tissues and is associated with poor prognosis in patients.• Knocking out MATR3 significantly inhibits the proliferation, migration, and invasion ability of colorectal cancer cells.• Animal experiments have confirmed that knocking out MATR3 can signifi...
Cheng-Kai-Chiu Huang, Xiao-Hui Jiang, W. Huang et al.· Translational Oncology· 0 citations
Highlights • RSPO1 is upregulated in cervical cancer.• RSPO1 promotes proliferation, migration, invasion, and tumorigenesis in vitro/vivo.• RSPO1 activates EGFR/Src/ERK/AKT axis via LGR4 in cervical cancer.• RSPO1-LGR4 stabilizes EGFR by blocking c-Cbl-mediated ubiquitination/degradation.
Li-Ting Lu, Xi-Duan Wei, Sai Liu et al.· Neoplasia· 0 citations
Highlights • NR3C2 expression is significantly decreased in triple-negative breast cancer and is associated with poor prognosis.• NR3C2 suppresses TNBC cell proliferation and migration both in vitro and in zebrafish xenograft models.• Transcriptomic analysis identifies NDUFB3 as a potential downstream target of NR3C2.•...
Here, Delahunty et al. identify that EP300 controls the growth of AKT-dysregulated osteosarcoma cells by regulating expression of state-specific genetic dependencies. AKT inhibitors synergize with EP300 degraders to suppress osteosarcoma growth in vitro and in vivo. These agents positively combine across cancer cells i...
Ian M. Delahunty, S. Nance, Yang Zhang et al.· Journal of Experimental Medi...· 0 citations
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