Oct 2026· Current Neurology and Neuroscience Reports· Vol 26· 0 citations· 41 references
Medicine
TL;DR
Recognizing neuroinflammation as this final common pathway reframes diagnosis around shared biomarkers rather than disease labels, predicts cross-disease therapeutic benefit, and relocates the therapeutic window earlier—toward protecting a brain vulnerable long before overt neurological disease declares itself.
Interventions discussed in this review are presented not as clinical recommendations for the general population, but as potential translational targets requiring validation in clearly defined VaD or vascular cognitive impairment subgroups.
Süheyla Ünal· Academia Neuroscience and Br...· 0 citations
Alzheimer's disease (AD) is now recognized as a biologically heterogeneous syndrome in which amyloid-β pathology, Tau-related alterations, and neuroinflammation are key interconnected processes. Microglia, astrocytes, oligodendrocytes, complement, inflammasomes, neurovascular cells, and peripheral immunity are implicat...
Priyanka Samantaray, Poonam Verma· Molecular and cellular neuro...· 0 citations
This review examines the molecular and cellular mechanisms through which neuroinflammation contributes to the progression of AD, with particular emphasis on microglial activation, TREM2 and soluble TREM2 (sTREM2) signaling, NLRP3 inflammasome activation, astrocyte–microglia interactions, and blood–brain barrier dysfunc...
Shreyansh Goswami· International Journal For Mu...· 0 citations
Evidence is synthesized on various PTMs such as phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, S-nitrosylation, and metabolite-coupled modifications, including lactylation and succinylation that have the potential to enhance biomarker-guided disease stratification and inform the...
Alzheimer’s disease (AD) is the leading cause of dementia worldwide, characterized by progressive cognitive decline and neurodegeneration. Although amyloid-β plaques and hyperphosphorylated tau are major pathological hallmarks, increasing evidence highlights persistent neuroinflammation as a critical contributor to dis...
Poonam, RE Rana, Mohita Thakur et al.· Frontiers in Oncology· 13 citations· ⚡1
This review summarizes how astrocytes contribute to neuroinflammatory processes in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, central nervous system injury, infection, multiple sclerosis, epilepsy, and autism spectrum disorder.
Shi-Jun Peng, Le-Peng Wang, J. Ouyang et al.· MedComm· 0 citations
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