Jul 2026· Journal Of Vocational Health Studies· Vol 10, pp. 87-93· 0 citations
TL;DR
An unusual instance of chromoblastomycosis caused by F. pedrosoi in a woman from South Kerala with a preceding history of a leech bite is described, highlighting the importance of combining clinical examination, histopathology, fungal culture, and molecular sequencing for accurate diagnosis and effective management of this rare and chronic fungal infection.
Abstract
Background: Chromoblastomycosis is a chronic cutaneous and subcutaneous fungal infection caused by melanized or brown-pigmented fungi, most commonly Fonsecaea pedrosoi. Purpose: This case report describes an unusual instance of chromoblastomycosis caused by F. pedrosoi in a woman from South Kerala with a preceding history of a leech bite, highlighting the importance of combining clinical examination, histopathology, fungal culture, and molecular sequencing for accurate diagnosis and effective management of this rare and chronic fungal infection. Case: A 54-year-old housewife presented with a 3 × 2 cm erythematous plaque on the dorsal aspect of left hand at the site of anatomical snuffbox. She reported a history of leech bite four years back at the same site. Dark pigmented colonies were isolated on Sabouraud dextrose agar. Skin biopsy for histological analysis, revealed sclerotic bodies, and Sanger sequencing. The patient was treated with oral itraconazole for two months. Result: The diagnosis of chromoblastomycosis was confirmed through fungal culture, histopathological examination revealing sclerotic bodies, and Sanger sequencing identifying F. pedrosoi. The patient responded well to two months of oral itraconazole over two months, with no recurrence of lesions noted on follow-up. Conclusion: Accurate identification of chromoblastomycosis is crucial due to its resistance to treatment and varied clinical manifestations, which often lead to misdiagnosis. However, combining systemic antifungal therapy with physical and surgical modalities has been shown to improve outcomes such an atypical mode of transmission underscores the need for heightened clinical awareness, especially in endemic areas or among patients with unusual environmental exposures.
An unusual instance of chromoblastomycosis caused by F. pedrosoi in a woman from South Kerala with a preceding history of a leech bite is described, highlighting the importance of combining clinical examination, histopathology, fungal culture, and molecular sequencing for accurate diagnosis and effective management of this rare and chronic fungal infection.
Ashna Ajimsha, C. Study, Kasus Chromoblastomycosis et al.· 0 citations
Background Onychomycosis is one of the most common nail disorders worldwide and is predominantly caused by dermatophytes; however, infections caused by non-dermatophyte molds are increasingly recognized as important causes of nail disease. Case presentation We present a case of a 41-year-old male from Duhok, Iraq, with a 15-year history of Crohn's Disease. He presented with progressive discoloration, nail thickening, nail deformity, pain while walking and brittleness of the affected nail that had persisted for several months. He was diagnosed with onychomycosis due to Syncephalastrum species, confirmed by KOH microscopy and characteristic culture morphology. Molecular confirmation was not available to identify to the species level. The fungus was sensitive to itraconazole, nystatin, clotrimazole, amphotericin B, miconazole, and ketoconazole, but showed resistance to fluconazole and voriconazole. He was successfully treated using IV amphotericin B, topical clotrimazole, and nail surgery. Conclusions This case demonstrates that Syncephalastrum species can cause clinically significant onychomycosis and should not automatically be dismissed as laboratory contaminants. A combination of clinical assessment, direct microscopy, culture-based identification, and antifungal susceptibility testing is essential for establishing diagnosis and guiding appropriate management.
A. A. Saadullah, R. Kwizera· Medical Mycology Case Report...· 0 citations
K. ohmeri was successfully identified using Vitek-2, MALDI-TOF, and ITS (Internal Transcribed Spacer) area sequencing, while the Integral System Yeast Plus misidentified the isolate as Candida tropicalis.
Siti Nadliroh, Mardiastuti Wahid, Fithriyah Sjatha et al.· 0 citations
Human cutaneous myiasis caused by Hypoderma sinense is rarely reported and may be mistaken for common bacterial skin disease. A 3-year-old boy from a livestock-raising pastoral region of China presented with multiple painful subcutaneous nodules that had not responded to topical antibacterial treatment. Marked eosinophilia, elevated total IgE, and linear ultrasonographic structures raised suspicion of parasitic infestation. A larva was removed intact from the posterior neck lesion through a pre-existing punctum under local anesthesia. Whole-genome shotgun sequencing followed by de novo assembly generated a 16,888-bp mitochondrial contig containing a complete COI barcode region, supporting identification of the larva as H. sinense. At the one-month follow-up, the pain and subcutaneous nodules had resolved. This case highlights the importance of considering cutaneous myiasis in children from livestock-raising regions with painful, treatment-resistant subcutaneous nodules and demonstrates the diagnostic value of ultrasonography, minimally invasive larval extraction, and molecular identification.
Qiuqin Ji, Shuyao He, Sha Lai et al.· Tropical Medicine and Health· 0 citations
Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm that may present with isolated cutaneous involvement or multisystem disease. In adults, cutaneous manifestations are often polymorphic and may mimic more common dermatologic conditions, leading to delayed diagnosis. A 41-year-old woman with a history of treated breast carcinoma presented with a two-year history of chronic erosive lesions involving the vulvar and intertriginous regions. Additional lesions affected the scalp, retroauricular folds, umbilicus, and external auditory canals. Histopathological examination of a vulvar biopsy, supported by positive CD1a and S100 immunostaining, confirmed the diagnosis of LCH. A comprehensive extension workup revealed no evidence of visceral, pulmonary, lymph node, or skeletal involvement. The patient was treated with topical clobetasol propionate, local wound care, and treatment of secondary bacterial superinfection, resulting in marked improvement of the vulvar and intertriginous lesions during follow-up. Adult cutaneous LCH remains a diagnostic challenge because of its ability to mimic inflammatory and infectious dermatoses, particularly when flexural and genital areas are affected. Histopathological examination with immunohistochemical confirmation is essential for establishing the diagnosis and guiding further evaluation. LCH should be considered in the differential diagnosis of persistent erosive vulvar and intertriginous lesions that are unresponsive to conventional therapies. Early biopsy is crucial to avoid diagnostic delay and to ensure appropriate staging and management.
Lamis El Yamani, O. Hormi, S. Moujahid et al.· Cureus· 0 citations
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