Chronic Fluoride Exposure Disrupts Calcium-Dependent Neurodevelopmental Signalling and Brain Proteomic Architecture: Multi-Target Modulation by Naringin

Ravindra Shantakumar Swamy Shalini Choudhary Abhishek Ambawatiya Vishal Chhabra Mayank Mishra M. Abubakar Smita Shenoy Naveen Kumar R. L. Gajbhiye Amita Rai V. Ravichandiran Nitesh Kumar

Aug 2026 · Biological Trace Element Research · Vol 204, pp. 8164 - 8185 · 0 citations · 61 references

Medicine

TL;DR

Co-treatment with naringin significantly alleviated behavioural impairments, restored antioxidant balance, reduced fluoride accumulation, mitigated dysregulation across multiple molecular pathways, and lessened changes in both proteomic and transcriptional markers, indicating a protective effect across multiple targets.

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