Background: Diabetes mellitus (DM) is an extremely complex metabolic disorder, with many factors contributing to persistent hyperglycaemia, redox dysregulation, and micro- and macrovascular damage over time. There is growing evidence that oxidative stress is one of the main mechanisms of β-cell damage, insulin resistan...
K. Adhikary, Thirtsha Shohani Godwin, Adsaya Karunanithi et al.· Pharmaceutics· 0 citations
Statins are widely regarded as the gold standard first-line treatment for hyperlipidemia, as they inhibit HMG-CoA reductase in the liver. This effectively reduces LDL cholesterol levels and reduces cardiovascular risks, such as heart attack and stroke. Simvastatin is a well-established, effective, and cost-efficient st...
A. Karmakar, Varla Yalamanda, Y. Khairnar et al.· AAPS PharmSciTech· 0 citations
Co-treatment with naringin significantly alleviated behavioural impairments, restored antioxidant balance, reduced fluoride accumulation, mitigated dysregulation across multiple molecular pathways, and lessened changes in both proteomic and transcriptional markers, indicating a protective effect across multiple targets...
Ravindra Shantakumar Swamy, Shalini Choudhary, Abhishek Ambawatiya et al.· Biological Trace Element Res...· 0 citations
This review explores the biological properties of exosomes, recent engineering advances to improve their therapeutic potential, and new methods to leverage their versatility for selective delivery of remedial agents to the brain and provides a roadmap for harnessing these methods effectively as medical interventions fo...
M. Abubakar, Ritu Dahiya, Lokesh Nama et al.· CNS and Neurological Disorde...· 0 citations
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