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Review Open access Sep 2026

Stem Cell-Based Therapies for Central Nervous System Demyelinating Diseases: Clinical Evidence, Therapeutic Niches, and Translational Boundaries

Central nervous system demyelinating disorders differ substantially in pathobiology, reversibility, and capacity for tissue repair. Disease-modifying therapies can suppress inflammatory activity in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but they do not replace lost oligodendrocytes...

Qian-Ping Luo, Dong-Gan Jin, Zhen-Ying Zhan · 0 citations
Review Open access Sep 2026

Applications of Mesenchymal Stromal Cells for Treatment of Diseases

This review provides a comprehensive framework for developing safer, standardized, and clinically transformative therapies based on MSCs, and explores emerging strategies to enhance the activity of MSCs, including pretreatment and activation, lifestyle intervention, and genetic engineering techniques.

Dong-Mei Xue, Yong-Sheng Li, Lei Wu · 0 citations
Conference Open access 2026

Mesenchymal Stem Cell Therapy for Idiopathic Pulmonary Fibrosis: Advances and Perspectives

Idiopathic pulmonary fibrosis (IPF) is a pulmonary disorder of unidentified etiology that advances relentlessly over time. The disorder features unrelenting parenchymal scarring that eventually brings about a deterioration in life quality and premature death. The disease advances gradually with a bleak prognosis, and f...

Yuwen Zou · 0 citations
Review Sep 2026

Mesenchymal Stem Cell Transplantation as Regenerative Therapy for Type 1 Diabetes: A Systematic Review

Type 1 diabetes is a chronic autoimmune disorder characterized byimmune-mediated destruction of pancreatic beta cells, resulting in lifelong dependence on exogenous insulin and risk of acute and chronic metabolic complications. Despite advances in insulin formulations and glucose monitoring technologies, current therap...

Mukisa Ian Mugaiga · 0 citations
Review Open access Sep 2026

Immunomodulatory Properties of Mesenchymal Stem Cells and Their Extracellular Vesicles: Potential Clinical Applications in Autoimmune Diseases

Mesenchymal stem cells (MSCs)/mesenchymal stromal cells and their extracellular vesicles (EVs), particularly exosomes, have emerged as therapeutic candidates in regenerative medicine due to their multipotency, low immunogenicity, and extensive immunomodulatory properties. This narrative review provides a narrative synt...

E. Ciarrochi, Juan B. Ciarrochi · 0 citations
Review Open access Aug 2026

Harnessing stem cells for regenerative medicine: Current applications and future prospects

A comprehensive literature review of preclinical models and clinical trials focusing on mesenchymal, hematopoietic, and pluripotent stem cells, evaluating their efficacy, safety, and manufacturing challenges found stem cell therapies demonstrate remarkable healing potential.

Somayeh Shamlou, H. Rostami, Ali Hassanzadeh et al. · 0 citations

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