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运动对炎症性肠病患者心理健康、生活质量和炎症状态的影响:Meta分析与系统综述

Sep 2026 · 医学健康与临床实践
Inflammatory Bowel Disease

Abstract

关注炎症性肠病(Inflammatory bowel disease,IBD)患者的心理健康及生活质量尤为重要,亟需改善患者精神状态的非药物治疗策略,本研究发现运动可能是一种有效辅助治疗IBD的手段。经检索PubMed、the Cochrane Library、Embase、Web of Science、CNKI和 WanFang Data等数据库,由2位研究者独立筛选文献、提取资料并评价偏倚风险;采用 Stata 16.0 进行 Meta 分析,Begg's 检验评估发表偏倚,逐一剔除法进行敏感性分析。最后共纳入7篇文献(含11项研究),发现:运动干预后,患者的心理健康(SMD= 0.40,95% CI 0.19~0.61,P < 0.01)和生活质量(SMD= 0.36,95% CI 0.16~0.55,P < 0.01)显著改善;而 C反应蛋白(SMD = -0.19,95% CI -0.55~0.17,P= 0.30)和粪钙卫蛋白(WMD= 18.59,95% CI -25.44~62.61,P= 0.41)水平与对照组相比无显著差异。本研究提示,运动干预可能改善IBD患者的心理健康和生活质量,但未显著改变其CRP和FC水平,因置信区间较宽,不能排除潜在影响。运动对IBD炎症状态的影响仍需大样本随机对照试验验证。合理的运动处方可能作为改善IBD患者心理健康和生活质量的辅助手段,其安全性需进一步确认。

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