A risk stratification framework comprising 14 DRGs that showed moderate prognostic performance in CRC was developed, and METTL9 was identified as overexpressed in CRC tissues, showed association with unfavorable clinical outcomes, and exhibited enhanced proliferative and migratory capacities in CRC cells.
Findings indicate telomere maintenance-related gene signature could serve as a preliminary auxiliary risk stratification tool for postoperative CRC patients, and PDE1B may also serve as a potential epithelial tumor-suppressor target for future preclinical studies.
Feng-Chan Huang, Jung-Yin Fong, C. Ng et al.· Frontiers in Molecular Biosc...· 0 citations
BACKGROUND
Thyroid carcinoma (THCA) represents the most prevalent malignancy of the endocrine system. Although the majority of patients exhibit favorable clinical outcomes, a subset still faces significant clinical challenges, including distant metastasis, recurrence, and poor response to therapeutic interventions, all...
Liang Chen, Chao-Hon Fu, Yang Chen et al.· Advances in Clinical and Exp...· 0 citations
Colorectal cancer (CRC) remains a leading cause of cancer mortality. This study investigates the prognostic and immunological role of neural-related genes (NRGs) in CRC. Using The Cancer Genome Atlas (TCGA) data, a four-gene signature (POU4F1, KLC3, ATP2A1, CALB2) was constructed via Cox and least absolute shrinkage an...
ObjectiveProstate cancer (PCa) lacks reliable biomarkers to distinguish indolent from aggressive tumors. Tryptophan metabolism (TM) participates in regulating tumor immunity and malignant progression, yet its prognostic relevance in PCa remains poorly characterized.MethodsTranscriptomic and clinical data of TCGA-PRAD c...
An-Ding Gao, Yi-Chen Xu, Ting-Ting Wang et al.· Science in progress· 0 citations
Background Colorectal cancer (CRC) exhibits marked molecular heterogeneity, yet prognostic tools centered specifically on protein kinases remain scarce. This study aimed to identify kinase-related molecular subtypes of CRC and to develop and validate a kinase-based prognostic risk model integrating clinical and immune...
Chao-Long Shen, Chang-Min Ding, Xiao-Feng Han et al.· Translational Cancer Researc...· 0 citations
Platelets are key components of the tumor microenvironment that contribute to colorectal cancer (CRC) progression. However, effective platelet-related prognostic tools for CRC risk stratification and prognostic assessment are lacking. Therefore, we aimed to develop a platelet-related prognostic model to improve risk st...
Yun-Yi Xie, Jun Li, Zu-Wei Yan et al.· International Journal of Mol...· 0 citations
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