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Open access Sep 2026

ISGylation promotes ALDOA stability and PKM2-dependent activation to fuel colorectal cancer metabolism

ISG15 overexpression in cancers has emerged as a diagnostic marker and therapeutic target. This study identifies ISGylation, a post-translational modification mediated by ISG15, as a critical driver of CRC progression through metabolic reprogramming and oncogenic signaling. Clinical and multi-omics analyses reveal el...

Ye Wang, Peng Yang, Chi Jin et al. · 0 citations
Open access Sep 2026

Depression-related gene signature characterizes prognostic subtypes and therapeutic sensitivities in colorectal cancer

A risk stratification framework comprising 14 DRGs that showed moderate prognostic performance in CRC was developed, and METTL9 was identified as overexpressed in CRC tissues, showed association with unfavorable clinical outcomes, and exhibited enhanced proliferative and migratory capacities in CRC cells.

Qiang Xu, Gang Hu, Ning-Jie Sun et al. · 1 citation

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