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TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Jian Meng Yong Wang Jing-Hui Wang Yi-Qing Chen Zi-Hao Zhao Zi-Qian Tang Jing Cao Xian Zhang Hong Luo Hui-Hui Li Yi-Li Wu Ying-Jun Zhao Wei-Hong Song Yun-Wu Zhang
Sep 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 55 references
Medicine

Abstract

Microglia‐mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer's disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood.

DOI PubMed Semantic Scholar
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