Computational antibody design requires representations that capture the geometric patterns underlying antigen--antibody interactions, yet existing approaches often rely on scalar distances or surface-intrinsic features, leaving cross-molecular geometry largely implicit. We present AbGaze, an end-to-end antibody design framework based on attentive geometric representation learning, which encodes distance, spatial direction, and surface-normal orientation of antigen surfaces relative to antibody-residue local frames, and adaptively aggregates these geometric interactions according to their interfacial context. The learned interaction representation is shared across multi-CDR co-design, complex structure prediction, and affinity optimization, with local-frame geometric supervision further constraining the representation. AbGaze outperforms prior methods across all three tasks: relative to the second-best method, it improves amino-acid recovery by 7.1% and reduces structural error by 14.9% on average over the six CDRs, improves interface docking quality (DockQ) by 6.6%, and raises the affinity improvement rate (IMP) by 32.5%.
GAOKAO-Bench is introduced, an intuitive benchmark that employs questions from the Chinese GAOKAO examination as test samples, including both subjective and objective questions that contribute a robust evaluation benchmark for future large language models and offers valuable insights into the advantages and limitations...
Xiaotian Zhang, Chun-yan Li, Yi Zong et al.· arXiv.org· 216 citations· ⚡17
This work investigates the possibilities of using LLMs in a resume screening setting via a document retrieval framework that simulates job candidate selection and finds that the MTEs are biased, significantly favoring White-associated names in 85% of cases and female-associated names in only 11.1% of cases.
This paper presents a comprehensive overview of the Ultralytics YOLO family, emphasizing architectural evolution, benchmarking, deployment, and emerging directions from YOLOv5 through YOLO27, and examines detection, segmentation, depth, classification, pose, oriented detection, tracking, export, quantization, and deplo...
A novel threat is unveiled in which attackers steer the RAG system's response by injecting malicious passages into its knowledge base, enabling the attacker to steer the response without altering the user input or modifying the RAG weights.
Jiaqi Xue, Meng Zheng, Yebowen Hu et al.· arXiv.org· 109 citations· ⚡8
This work revisits schema linking when using the latest generation of large language models (LLMs) and finds empirically that newer models are adept at utilizing relevant schema elements during generation even in the presence of large numbers of irrelevant ones.
Karime Maamari, Fadhil Abubaker, Daniel Jaroslawicz et al.· arXiv.org· 109 citations· ⚡19
Empirically, PRISM reduces the end-to-end time for data selection and model tuning to just 30% of conventional pipelines, and achieves this efficiency while simultaneously enhancing performance, surpassing models fine-tuned on the full dataset across eight multimodal and three language understanding benchmarks.
Jinhe Bi, Yifan Wang, Danqi Yan et al.· arXiv.org· 73 citations· ⚡4
With $2.1 million funding from Google.org, the open-source Public Transit Intelligence Hub will unify public transit monitoring, operations, and passenger communication.
Professor Sherry Turkle’s new book, “Artificial Intimacy,” offers a withering critique of chatbots and the antisocial dynamics she believes they encourage.
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