Protein optimization remains a longstanding goal in life sciences. Existing machine learning-assisted directed evolution (MLDE) methods primarily rely on sequence-only features, overlooking the critical spatial constraints and co-evolutionary interactions encoded in protein structures. However, directly integrating str...
Zi-Kun Nie, Su-Yuan Zhao, Yi-Zhen Luo et al.
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Single-cell transcriptomics enables profiling of cellular states at unprecedented resolution, but its high dimensionality, sparsity, and technical batch effects pose significant challenges for representation learning. Existing single-cell foundation models typically encode each cell independently or only model cells fr...
Su-Yuan Zhao, Ming-Hao Liu, Yi-Zhen Luo et al.
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Computational antibody design requires representations that capture the geometric patterns underlying antigen--antibody interactions, yet existing approaches often rely on scalar distances or surface-intrinsic features, leaving cross-molecular geometry largely implicit. We present AbGaze, an end-to-end antibody design...
Jia-Shuo Wang, Si-Qi Fan, Yi-Zhen Luo et al.
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