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Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

Cheng-Zhang Zhu Zhi-Yan Zhao Bo-Jun Song Yan-Ming Chen Yu Xiao Zhe Zhang Ying-Zhi Ye Nian-Nian Xu Rui-Jia Zhang Yong-Xin Huang Juan C. Troncoso Chuan He Shu-Ying Sun
Sep 2026 · bioRxiv · 0 citations · 6 references
Medicine Biology

TL;DR

It is shown that TDP-43 depletion in human neurons induces widespread circRNA changes, especially upregulation of a distinct class of cryptic circRNAs that arise specifically upon loss of TDP-43, and establishes these circRNAs as stable molecular signatures of TDP-43 dysfunction.

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