Yong-Xin Huang

Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

It is shown that TDP-43 depletion in human neurons induces widespread circRNA changes, especially upregulation of a distinct class of cryptic circRNAs that arise specifically upon loss of TDP-43, and establishes these circRNAs as stable molecular signatures of TDP-43 dysfunction.