TREM2 remains a promising but context-sensitive therapeutic target that functions within a context-dependent framework in which gene dosage, disease stage, pathological substrate, microglial state, and activation duration jointly determine protective or maladaptive outcomes.
It is proposed that the therapeutic value of TREM2 is best understood through the concept of therapeutic window, and soluble TREM2 (sTREM2) should be interpreted cautiously, as it may reflect receptor shedding, target engagement, microglial state, disease stage, or a combination of these processes rather than serving a...
Qi-Xia Kuang, Shu-Jun Li, Wen-Di Huang et al.· Frontiers in Aging Neuroscie...· 0 citations
This review examines the molecular and cellular mechanisms through which neuroinflammation contributes to the progression of AD, with particular emphasis on microglial activation, TREM2 and soluble TREM2 (sTREM2) signaling, NLRP3 inflammasome activation, astrocyte–microglia interactions, and blood–brain barrier dysfunc...
Shreyansh Goswami· International Journal For Mu...· 0 citations
Alzheimer’s disease (AD) is one of the leading neurodegenerative disorders affecting over 55 million
individuals worldwide, with a limited selection of disease-modifying therapies. The amyloid cascade
hypothesis proposes that amyloid-beta (Aβ) peptide accumulation initiates a cascade of synaptic
dysfunction, neuroinfla...
Rhea Menon· American Journal of Student...· 0 citations
Alzheimer’s Disease (AD) is a neurodegenerative disorder with
progressive cognitive decline, β-amyloid plaques, neurofibrillary tangles, oxidative stress,
and neuroinflammatory responses. So far, the pathogenesis of AD has been explained by
the cholinergic hypothesis, amyloid cascade hypothesis, and tau protein dys...
Lalit Parihar, A. Singh, Sanjar Alam· Current Pharmacogenomics and...· 0 citations
Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disorder involving metabolic dysfunction, neuroinflammation, mitochondrial impairment, synaptic failure, and neuronal loss. Although amyloid-beta deposition and neurofibrillary tangles composed of hyperphosphorylated tau remain central patho...
Jefferson Muniz Alves da Silva, A. Kümmerle, D. A. Rodrigues et al.· Future Medicinal Chemistry· 0 citations
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that affects millions of people worldwide and poses a major global health challenge. This complex disease involves multiple pathogenic factors, including amyloid-beta (Aβ), tau protein aggregation, synaptic dysfunction, mitochondrial impairment, oxida...
Mona Piplani, Shivani Thakur, Pankaj Kumar et al.· Biomedical & Pharmacolog...· 0 citations
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