Longévité OS : Compendium libre des biomarqueurs du vieillissement et des protocoles d'intervention open source

Abstract

Abstract EN This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). We disclose 77 enabling embodiments spanning assays/kits (telomeres, DNAm clocks, glycan-age, proteome, microbiome, metabolome, cfDNA-CHIP, mtDNA, 8-oxo-Gsn, NAD⁺), devices/sensors (AGE autofluorescence, VOP/PPG, continuous/interstitial NAD), AI/analytics (composite age, brain-age MRI, multimodal transformer, federated/DP, MLOps/QC), closed-loop protocols (senolytics, NAD scheduling, mTOR pre-vaccination, TRIIM-like, hormesis), delivery (microneedles, exosomes), imaging (MRI/MRS), and compliance/operations (FHIR consent, ATEX enclosures, logistics, calibration-as-a-service). Each proposal includes SOP-level parameters, IPC/CPC classifications, and timestamp proof (RFC 3161 / FreeTSA). Abstract FR Ce document, produit avec l’assistance de ChatGPT o3 et ChatGPT 5 Thinking, est diffusé sous licence Apache 2.0. Il constitue une publication défensive volontaire (prior art) et entre donc dans l’état de la technique dès sa mise en ligne au regard des lois applicables : EPC Art. 54(2) (Convention sur le brevet européen), French IPC Art. L 611-11 (Code de la propriété intellectuelle), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法) et Japanese Patent Act Art. 29(1) (特許法). Nous divulguons 77 réalisations “enabling” couvrant essais/kits (télomères, horloges DNAm, glycan-age, protéome, microbiome, métabolome, cfDNA-CHIP, ADNmt, 8-oxo-Gsn, NAD⁺), dispositifs/capteurs (AGE cutané, VOP/PPG, NAD continu), IA/analytique (âge composite, brain-age IRM, transformer multimodal, fédéré/DP, MLOps/QC), protocoles en boucle fermée (sénolytiques, planification NAD, mTOR pré-vaccination, TRIIM-like, hormèse), délivrance (microneedles, exosomes), imagerie (IRM/MRS) et opérations/conformité (consentement FHIR, boîtiers ATEX, logistique, calibration-as-a-service). Chaque proposition inclut des paramètres de niveau SOP, des classes IPC/CPC et une preuve d’horodatage (RFC 3161 / FreeTSA). Timestamp : 2025-08-08T18:41:00ZSHA-256 : d23149bb7f0403edb1a1385ba16328c7e961d47848edd205893ba02dcf2911ce Innovations & Classifications (IPC ; CPC) : 1 — Standardized telomere qPCR kit ; C12Q 1/68 ; C12Q 1/68862 — Low-cost DNAm clock + pipeline ; C12Q 1/68 ; G16H 10/603 — Federated privacy-preserving clock ; G16H 50/20 ; G06N 20/104 — p16INK4a T-cell RT-qPCR kit ; C12Q 1/68 ; G01N 33/5695 — Multiplex SASP blood panel ; G01N 33/68 ; G16H 10/606 — 12-protein proteomic age ; G01N 33/53 ; G16H 10/607 — DBS GlycanAge ; G01N 33/68 ; G01N 33/688 — Bi-spectral skin AGE reader ; A61B 5/145 ; A61B 5/14559 — Cuffless PPG PWV ; A61B 5/00 ; A61B 5/10310 — VO2max smartphone ; A61B 5/00 ; G16H 50/2011 — IMU frailty (grip+gait) ; A61B 5/11 ; A61B 5/11712 — Combined NAD+ proxy ; G01N 33/92 ; G16H 10/6013 — Chrono NAD stack (AM/PM) ; A61K 31/00 ; A61P 43/0014 — Pulsed senolytic protocol ; A61K 36/00 ; A61P 43/0015 — Senolytic microneedle patch ; A61M 37/00 ; A61M 37/006616 — Controlled autophagy cycle ; A61K 31/00 ; A61P 43/0017 — Personalised mito-cocktail ; A61K 31/00 ; A61P 21/0018 — Cold+exercise BAT tracking ; A61H 15/00 ; A61B 5/14519 — Guided thymic regeneration ; A61K 38/00 ; G16H 40/6320 — Anti-aging plasma exchange ; A61M 1/36 ; A61M 1/3621 — Rejuvenation FMT + prebiotics ; A61K 35/742 ; A61P 1/0022 — Composite age score (BACs) ; G16H 50/20 ; G06N 20/0023 — DBS logistics & stabilization ; G01N 1/28 ; B65D 81/3624 — Biological-age MLOps ; G16H 50/20 ; G06F 11/3625 — Objective skin protocol ; A61Q 19/00 ; A61B 5/14526 — Anti-AGEs cooking assistant ; G16H 40/20 ; G06N 20/0027 — Thymus MRI segmentation ; A61B 5/055 ; G06N 20/0028 — Digital age biomarkers ; G16H 50/20 ; G06N 20/0029 — Smartphone AGE clip ; G01N 21/64 ; A61B 5/145530 — RL NAD personalized loop ; G16H 20/10 ; A61P 43/0031 — Fingerstick autophagy chip ; B01L 3/00 ; C12Q 1/68832 — Lab-on-chip respirometry ; G01N 33/68 ; B01L 3/502733 — PWV+Grip phone case ; A61B 5/11 ; A61B 5/14534 — Hematology Age Index ; G16H 40/20 ; G06N 20/0035 — Inflammaging triage ; G01N 33/68 ; G16H 40/2036 — Aptamer proteomic clock ; G01N 33/68 ; G16H 40/2037 — Transcriptomic Age Lite ; C12Q 1/68 ; G06N 20/0038 — Microbiome Age Kit ; C12Q 1/6895 ; G16H 40/2039 — cfDNA CHIP monitor ; C12Q 1/6883 ; G16H 40/2040 — mtDNA Copy Chip ; C12Q 1/68 ; G01N 33/6841 — Circadian dual patch ; A61B 5/00 ; G01N 33/6842 — Hormetic Trio Optimizer ; G16H 40/20 ; A61H 33/0043 — GlycanAge coach ; G16H 40/20 ; G01N 33/6844 — CD38 nano-inhibitor therapy ; A61K 31/708 ; A61K 31/708845 — Anti-uPAR CAR-T senolytics ; C12N 15/90 ; A61K 35/1746 — Transient AAV-OSKM reboot ; C12N 15/90 ; C12N 15/902347 — Multi-omic age dashboard (AI) ; G16H 50/20 ; G16H 50/7048 — Wearable NAD patch ; G01N 27/327 ; G01N 27/41749 — Home epigenetic chip ; C12Q 1/688 ; C12Q 1/689250 — Brain-Age MRI (SaaS) ; A61B 5/055 ; G06T 7/6051 — Rapa + D+Q + exercise stack ; A61K 31/70 ; A61P 37/0252 — Skin exosome patch ; A61K 35/51 ; A61K 35/50553 — Implantable NAD sensor ; G01N 21/31 ; G01N 21/31154 — Nanopore microbiome clock ; C12Q 1/686 ; C12Q 1/689255 — IMM-AGE flow panel ; G01N 33/53 ; G01N 33/54356 — Stabilised blood NAD LC-MS ; G01N 33/68 ; G01N 33/689557 — mTOR pre-vaccination ; A61K 31/7048 ; A61P 37/0858 — Brain MRS-NAD pipeline ; A61B 5/055 ; G06T 7/0059 — HRV+CGM fasting triggers ; A61B 5/024 ; G16H 40/6760 — Spermidine microneedle patch ; A61M 37/00 ; A61K 31/21661 — Home skin+grip app ; G16H 20/20 ; A61B 5/0062 — Glycan-age & weight loss ; G01N 33/68 ; C07K 14/0063 — Urinary 8-oxo-Gsn kit ; G01N 30/72 ; G01N 33/6864 — IL-7 pre-vaccination ; A61K 38/00 ; A61P 37/0865 — Anti-CCR5 anti-SASP ; A61K 31/506 ; A61P 37/0666 — MetaboAge LC-MS ; G01N 30/86 ; G01N 33/6867 — Targeted AGEs CML/pentosidine ; G01N 33/68 ; G01N 33/689568 — 4-m walk smartphone ; A61B 5/11 ; G16H 20/2069 — Sleep/HRV circadian index ; A61B 5/024 ; G16H 40/6770 — HRT guided by glycan-age ; G16H 50/20 ; A61P 19/0271 — Reprogramming monitoring ; G16H 50/20 ; G06N 20/0072 — Longevity multivitamin QA ; A61K 31/00 ; A61K 31/0073 — Basic sleep coach ; G16H 40/20 ; G16H 40/6774 — AOPP spectrophotometric assay ; G01N 33/68 ; G01N 33/6875 — Classic Age Analytics (GBM) ; G16H 50/20 ; G06N 20/0076 — ATEX-rated sensor enclosure ; H05K 7/14 ; H05K 7/1477 — Consent & data governance registry ; G16H 10/60 ; G06F 21/62 Keywords telomere, qPCR, standardization, epigenetic clock, methylation, pipeline, federated learning, privacy, biological age, p16, T cells, immunosenescence, SASP, cytokines, multiplex, proteomics, age model, ELISA, IgG glycan, UPLC, DBS, autofluorescence, skin AGE, optical, pulse wave, PPG, arterial stiffness, VO2max, submax test, smartphone, gait, IMU, frailty, NAD, lactate-pyruvate, CD38, NMN, apigenin, chronotherapy, senolytics, fisetin, quercetin, microneedle, transdermal, senolytic, autophagy, spermidine, HIIT, mitochondria, CoQ10, lipoic acid, brown fat, thermography, cold, thymus, IL-7 surrogate, TRIIM, plasma exchange, albumin, NfL, microbiome, FMT, prebiotic, composite age, multi-omics, ML, DBS, stabilization, preanalytics, MLOps, calibration, drift, retinoid, sunscreen, fractional laser, dietary AGEs, recommendation, feedback, MRI, segmentation, thymus, digital biomarker, voice, HRV, autofluorescence, smartphone, skin, NAD, reinforcement-learning, dosing, autophagy, fingerstick, LC3, respirometry, oxygen, lab-on-chip, PWV, handgrip, adapter, CBC, hematology, age index, IL-6, CRP, workflow, aptamer, proteomic clock, QC, transcriptomic, RNA-seq, age, microbiome, 16S, age clock, CHIP, cfDNA, dPCR, mtDNA, copy number, deletions, cortisol, melatonin, patch, hormesis, sauna, polyphenols, glycan-age, coaching, IgG, CD38, nanoparticle, NAD, CAR-T, uPAR, senescence, OSKM, AAV, partial reprogramming, transformer, explainable AI, multimodal, wearable, NAD sensor, microfluidic, epigenetic chip, fingerstick, mobile, brain-age, MRI, domain adaptation, rapamycin, senolytics, exercise, exosome, hydrogel, skin, implantable, fluorescence, NAD, nanopore, microbiome, age, immunosenescence, flow cytometry, IMM-AGE, NAD, LC-MS, preanalytics, MRS, NAD, brain, HRV, fasting, closed-loop, microneedle, spermidine, transdermal, skin-AGE, grip, app, glycan-age, weight-loss, UPLC, 8-oxo-Gsn, urine, HPLC-MS, IL-7, vaccination, thymic, CCR5, maraviroc, SASP, metabolomics, age-model, LC-MS, CML, pentosidine, AGEs, gait-speed, smartphone, frailty, sleep, HRV, circadian, HRT, glycan-age, menopause, OSKM, monitoring, epigenetic, multivitamin, QC, SPC, sleep-hygiene, coaching, PSQI, AOPP, oxidative-stress, spectrophotometry, gradient-boosting, SHAP, calibration, ATEX, enclosure, ruggedization, consent, FHIR, governance