TL;DR
It is indicated that HOTAIR aggravates hyperuricemia-induced endothelial injury by regulating the miR-141-3p/GPR75/NF-κB axis and provides new mechanistic insights into hyperuricemia-associated vascular dysfunction.
Findings reveal that the LINC01419–miR-132-3p–USP38 axis mediates ferroptosis in vascular endothelial cells under hyperglycemia, and suggest USP38 as a potential therapeutic target for T2DM.
OBJECTIVE Pulmonary hypertension (PH) involves endothelial-to-mesenchymal transition (EndMT) in vascular remodeling. Rosiglitazone (RSG), a peroxisome proliferator-activated receptor gamma agonist, alleviates PH, but its direct effect on EndMT is unclear. The study explores RSG's role and mechanism in inhibiting EndMT....
BACKGROUND Disordered glucose and lipid metabolism exacerbates endothelial injury, promoting atherosclerosis (AS). This study aimed to elucidate the role of the lncRNA MALAT1 in endothelial injury under high glucose and palmitic acid (HGPA) conditions via in vivo and in vitro experiments. METHODS Bioinformatics ident...
INTRODUCTION Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by disrupted hepatic lipid homeostasis and progressive liver injury, and frequently coexists with hypertension and systemic vascular remodeling, suggesting shared pathophysiological mechanisms. Although adipose tissue-derived microRNA...
Background: Diabetes mellitus is characterized by chronic hyperglycemia, which promotes oxidative stress and endothelial dysfunction. MicroRNAs (miRNAs) have emerged as important regulators of diabetic vascular complications. Our previous RNA-sequencing study identified putative novel miR-1133 as an upregulated miRNA i...
BACKGROUND TIE1 is an endothelial receptor tyrosine kinase, which plays a crucial role in vascular development and remodeling, including in diseases such as diabetic retinopathy (DR). However, the molecular mechanisms and regulatory interactome governing TIE1 function remain largely unknown. Long noncoding RNAs (lncRNA...
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