This Review provides insights into the challenges and gaps for translation, manufacturing and expansion of lipid nanoparticle-mediated nucleic acid therapeutics for precision RNA medicine while highlighting next-generation principles and translational perspectives that may guide precision RNA therapeutics in regenerative medicines.
The importance of formulation optimization in improving nucleic acid delivery is highlighted and practical insights for enhancing peptide- and lipid-based therapeutic platforms are provided.
D. Daniele, Z. Hein, O. Saher et al.· International Journal of Pha...· 0 citations
Lipid nanoparticles (LNPs) are a clinically validated nonviral platform for the delivery of CRISPR-associated components. Composed of ionizable lipids, phospholipids, cholesterol, and PEG-lipids, LNPs enable the efficient encapsulation, protection, and cytosolic delivery of therapeutic cargo such as DNA, RNA, or protei...
A. Olsen, C. Brandt, Rasmus Karred Larsen et al.· Methods in molecular biology· 0 citations
This synthesis aims to guide formulation scientists, clinician‐scientists, and regulatory professionals in advancing the next generation of LNP‐based precision nanomedicines by linking molecular lipid design to manufacturing scalability, long‐term safety, and equitable access.
T. Ikrar, Wachyudi Muchsin, Alfi Sophian· European Journal of Lipid Sc...· 0 citations
This study develops a class of ionizable cholesterol derivatives by conjugating biocompatible dimethylated amino acids to cholesterol through a cleavable linker, thereby integrating the structural role of cholesterol and the pH‐responsive ionization of ions into a single molecule.
This review summarizes bioactive LNPs incorporating naturally sourced bioactive lipids, bioactive agent-derived lipids, or novel bioactive lipids identified through combinatorial synthesis coupled with high-throughput screening and provides perspectives on the challenges and opportunities in translating bioactive lipid...
Kaiqi Long, Jeffrey Yuan, Yang Zhang et al.· Materials Today· 0 citations
Ionizable lipid nanoparticles (LNP)-mediated siRNA delivery provides a promising technological platform for cancer gene therapy. Traditional cancer treatment methods primarily focus on directly killing tumor cells, but RNA interference-based siRNA therapy can regulate the expression of genes related to disease, represe...
Hao-Chen Xu· Theoretical and Natural Scie...· 0 citations
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