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Author

Lulu Xue

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Review Sep 2026

Structural evolution of ionizable lipids for nucleic acid delivery

This Review provides insights into the challenges and gaps for translation, manufacturing and expansion of lipid nanoparticle-mediated nucleic acid therapeutics for precision RNA medicine while highlighting next-generation principles and translational perspectives that may guide precision RNA therapeutics in regenerati...

Lu-Lu Xue, M. Ang, K. Swingle et al. · 0 citations
Jul 2026

Ligand-Mediated Reprogramming Redirects Liver-Tropic Ionizable Lipid Nanoparticles for Lung-Selective mRNA Delivery.

A ligand-mediated lipid reprogramming approach that repurposes chemically defined, liver-tropic, ionizable lipids (lipidoids) for mRNA delivery beyond the liver, and achieves outperformed efficacy and therapeutic potential in lung-specific genome editing relative to SORT-constructed 2-t6b LNP system.

Zhuxiao Gu, Xinhong Xiong, Xiang Chen et al. · 0 citations

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