The Tau-mitochondria connection and its impact on cellular energy metabolism in Alzheimer's disease.

Energetic crisis, mitochondrial vulnerability and disruption of lactate shuttle in Alzheimer's disease.

Cerebral bioenergetic metabolic failure as a central driver of cognitive decline, arising from irreversible reactive gliosis and neuroblastosis mechanisms is emphasised and various therapeutic options are highlighted, including restoration of ANLS to mitigate the pathogenesis and memory loss in AD.

Mitochondrial Calcium Dysregulation: A Central Nexus in Alzheimer’s Disease Pathogenesis and Therapeutic Intervention

The roles of mitochondrial calcium uniporter (MCU) complex and mitochondrial sodium – calcium – lithium exchanger (NCLX) in regulating mitochondrial Ca²⁺ along with the therapeutic effects of regulating mitochondrial Ca²⁺ in the brain are highlighted.

Metabolic therapeutic targets in Alzheimer's disease.

This chapter examines key metabolic pathways implicated in AD, including cerebral glucose hypometabolism, brain insulin resistance, impaired glycolysis, mitochondrial oxidative phosphorylation deficits, oxidative stress, and altered mitochondrial dynamics, and discusses therapeutic strategies aimed at restoring metabol...

Tau dysfunction in alzheimer’s disease: molecular and cellular mechanisms, genetic modulation, and therapeutic perspectives

Findings support a model in which tau dysfunction results from the convergence of molecular aberrations and genetic susceptibility within a pathological network involving amyloid-β, neuroinflammation, and synaptic failure.

Comprehensive insights into Alzheimer's disease: Amyloid-β pathology, tau dysfunction, and neurodegenerative mechanisms.

Targeting the mitochondrial functional network: Decoding upstream pathological mechanisms and novel therapeutic paradigms for Alzheimer's disease.

A novel interpretation of the aging-related pathogenic mechanisms of AD from a mitochondrial perspective is provided, a theoretical foundation for the development of precise and efficient mitochondria-targeted therapeutic strategies for AD is laid, and a new paradigm for breaking through the bottlenecks of clinical dia...