Energetic crisis, mitochondrial vulnerability and disruption of lactate shuttle in Alzheimer's disease.

Metabolic therapeutic targets in Alzheimer's disease.

This chapter examines key metabolic pathways implicated in AD, including cerebral glucose hypometabolism, brain insulin resistance, impaired glycolysis, mitochondrial oxidative phosphorylation deficits, oxidative stress, and altered mitochondrial dynamics, and discusses therapeutic strategies aimed at restoring metabol...

The Tau-mitochondria connection and its impact on cellular energy metabolism in Alzheimer's disease.

This chapter looks at the nature of the tau-mitochondrial interface, and proposes a paradigm of tau-induced energy failure in AD, and discusses novel therapeutic approaches that target both tau and mitochondrial abnormalities, namely antisense oligonucleotides (ASO), mitochondria targeted compounds and mitophagy modifi...

Brain energy crisis in Alzheimer's and Parkinson's disease: Nanotechnology as a therapeutic strategy.

Brain lipid dysregulation as a driver of energy metabolism failure in Alzheimer's disease.

This chapter addresses the gap and consolidates existing information connecting lipid modifications to metabolic dysfunction in AD, emphasizing molecular pathways and prospective treatment strategies aimed at lipid metabolism to re-establish bioenergetic equilibrium.

Disrupted astrocyte-neuron metabolic coupling in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by progressive loss of motor neurons. In addition to neurodegeneration, ALS is increasingly recognised as a disorder associated with widespread metabolic dysfunction, including hypermetabolism, weight loss, and dyslipidaemia, all of...

Roles of glycolytic and pyruvate metabolism enzymes in Alzheimer’s disease glycometabolic reprogramming and their therapeutic potential

Current evidence regarding the dysregulation of major glycolytic and pyruvate-metabolizing enzymes, including hexokinase (HK), phosphofructokinase-1 (PFK1), pyruvate kinase (PK), lactate dehydrogenase (LDH), and the pyruvate dehydrogenase complex (PDHc), in both neurons and glial cells are synthesized.