Open access
Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer
Lin Li
Nannan Zhu
Tao Zhu
Yuxuan Wang
Jieran Deng
Han Xie
Xiao-Yun Guo
Q. Duan
Lei Chen
Jingshan Tong
Xiang Wang
Medicine
Abstract
Highlights • The dual-target c-Met/VEGFR kinase inhibitor foretinib reshapes tumor immune microenvironment (TIME) by inducing immunogenic cell death (ICD).• We identified an on-target mechanism of foretinib in transcriptionally activating Drath Receptor 5 (DR5), a key component of the extrinsic apoptotic pathway.• The combination of foretinib with anti-CD47 antibody significantly inhibits tumor growth in colon cancer model.