Open access
Aug 2026
Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer
Highlights • The dual-target c-Met/VEGFR kinase inhibitor foretinib reshapes tumor immune microenvironment (TIME) by inducing immunogenic cell death (ICD).• We identified an on-target mechanism of foretinib in transcriptionally activating Drath Receptor 5 (DR5), a key component of the extrinsic apoptotic pathway.• The...
Lin Li, Nannan Zhu, Tao Zhu et al.
· Neoplasia · 0 citations